Investigating blood clotting related to vascular devices
Contact Pathway Activation on Vascular Devices
This study is looking at how certain medical devices, like stents and dialysis machines, can cause blood clots, and it aims to create safer blood-thinning medications to help patients avoid bleeding problems while still getting the care they need.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10892751 on NIH RePORTER |
What this research studies
This research focuses on how contact activation contributes to blood clotting and thrombus formation in patients using vascular devices like stents and hemodialyzers. The team aims to develop safer anticoagulant medications that minimize the risk of bleeding, which is a common complication with current treatments. By studying the mechanisms of blood coagulation in relation to these devices, the research seeks to identify new therapeutic strategies that could improve patient outcomes. The findings could lead to innovative treatments that are less toxic and more effective for patients requiring vascular interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who require vascular devices for medical treatments, particularly those at high risk for thrombotic events.
Not a fit: Patients who do not use vascular devices or who are not at risk for thrombotic complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of anticoagulants that significantly reduce bleeding risks for patients using vascular devices.
How similar studies have performed: Previous research has shown promise in developing safer anticoagulants, indicating that this approach has potential for success.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Mccarty, Owen J — Oregon Health & Science University
- Study coordinator: Mccarty, Owen J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.