Investigating blood clotting changes in women using oral contraceptives
TFPI, Protein S, and Plasma FIXa in Hormone-Induced Hypercoagulability
['FUNDING_R01'] · VERSITI WISCONSIN, INC. · NIH-10907694
This study is looking at how birth control pills might affect blood clotting in women, especially by checking certain proteins in the blood, to help identify those who may be at a higher risk for blood clots.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VERSITI WISCONSIN, INC. (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-10907694 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how oral contraceptives (OCs) affect blood clotting in women, particularly looking at the role of certain proteins that help regulate coagulation. The study aims to identify the pathways that lead to increased blood clotting risk, known as hypercoagulability, in women taking OCs. By analyzing blood samples, researchers will measure the activity of specific coagulation factors and explore genetic factors that may increase the risk of venous thromboembolism (VTE). This could help in identifying women who are at higher risk and understanding the biological mechanisms involved.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who are currently using oral contraceptives and may be concerned about their risk of blood clots.
Not a fit: Patients who do not use oral contraceptives or have no history of blood clotting disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better risk assessment and management strategies for women using oral contraceptives, potentially reducing the incidence of blood clots.
How similar studies have performed: Previous research has indicated that hormonal contraceptives can influence coagulation pathways, suggesting that this investigation builds on established findings in the field.
Where this research is happening
MILWAUKEE, UNITED STATES
- VERSITI WISCONSIN, INC. — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAST, ALAN E — VERSITI WISCONSIN, INC.
- Study coordinator: MAST, ALAN E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.