Investigating blood clotting and bleeding disorders using zebrafish
Genetic and therapeutic studies of hemostatic and thrombotic disorders using zebrafish
This study is looking at how genes affect blood clotting and bleeding disorders using zebrafish, with the hope of finding new ways to help people who are at risk for these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11060929 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic factors that influence blood clotting and bleeding disorders. By using zebrafish as a model organism, researchers will employ advanced genetic techniques, including CRISPR and next-generation sequencing, to identify genes that may modify the severity of these disorders. The goal is to uncover new therapeutic targets and improve patient classification for those at higher risk of complications. This approach aims to enhance our understanding of coagulation disorders and develop better treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diagnosed hemostatic or thrombotic disorders, including those experiencing excessive bleeding or clotting.
Not a fit: Patients without any coagulation disorders or those who do not have a genetic predisposition to such conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for patients with bleeding and clotting disorders.
How similar studies have performed: Previous research using zebrafish models has shown promise in understanding genetic factors in various diseases, indicating potential for success in this novel approach.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Shavit, Jordan a — University of Michigan at Ann Arbor
- Study coordinator: Shavit, Jordan a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.