Investigating blood changes in Alzheimer's disease over time
Official title: Longitudinal Blood-based Transcriptomic Changes in AD: Relation to Clinical and Biomarker Data
Funded at Mayo Clinic Jacksonville · NIH-11075370 · Data updated 2026-11-12
This study is looking at how certain blood markers change in people with Alzheimer's disease over time to help understand the disease better and see how well treatments are working.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | March 15, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,401,655 |
| NIH project number | 5U19AG074879-03 |
| Project ID | NIH-11075370 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias, particularly those from diverse ethnic backgrounds.
✕Less likely to help
Patients with early-stage cognitive impairment or those without a diagnosis of Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding how blood-based biomarkers change in patients with Alzheimer's disease (AD) over time. By analyzing samples from a large cohort, the study aims to identify patterns that correlate with clinical symptoms and other biomarkers. Patients will be monitored through multiple assessments, allowing researchers to track the progression of the disease and the effectiveness of potential treatments. The study utilizes advanced techniques, including multi-omics and neuroimaging, to gather comprehensive data on participants.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for diagnosing and monitoring Alzheimer's disease, potentially paving the way for more effective treatments.
How similar studies have gone: Previous research has shown promise in using blood-based biomarkers for Alzheimer's disease, but this study aims to take a novel approach by integrating multiple data types over time.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Saykin, Andrew J — Mayo Clinic Jacksonville
- Study coordinator: Saykin, Andrew J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.