Investigating blood cell development and diseases using genetically modified animals
Xenotransplant and Genome Editing Core
This study is looking at how blood cells grow and work in healthy and sick animals to help find new treatments for blood disorders, and it's designed for researchers who want to improve therapies for conditions like anemia or other non-cancerous blood diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10899713 on NIH RePORTER |
What this research studies
This research focuses on using genetically modified and immunocompromised animals to study how blood cells develop and function in both healthy and diseased states. By employing advanced techniques like genome editing and single-cell analysis, the project aims to uncover the molecular mechanisms behind various blood disorders. The core facility provides specialized mouse strains and services to streamline the process of cell transplantation assays, ultimately enhancing the efficiency of research in hematology. This work could lead to the development of new stem cell-based therapies for non-malignant blood diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with non-malignant hematological disorders who may benefit from advanced therapeutic modalities.
Not a fit: Patients with malignant blood disorders or those not affected by hematological conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for a range of blood disorders, improving patient outcomes.
How similar studies have performed: Previous research using similar animal models and genome editing techniques has shown promising results in understanding and treating blood diseases.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Starczynowski, Daniel — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Starczynowski, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.