Investigating blood-brain barrier issues in Alzheimer's disease
Blood-brain barrier dysfunction in Alzheimer's disease: from humans to animal models
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10884089
This study is looking at how changes in the blood-brain barrier might affect people with mild cognitive impairment and early dementia, hoping to find new ways to understand and treat Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10884089 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how damage to the blood-brain barrier (BBB) contributes to Alzheimer's disease and related dementias. Using advanced MRI techniques, the study aims to assess BBB permeability in patients with mild cognitive impairment and early dementia. By examining the relationship between BBB breakdown and key pathological features of Alzheimer's, the research seeks to uncover important insights into disease progression and cognitive function. This could lead to better diagnostic and therapeutic strategies for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with mild cognitive impairment or early stages of Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown promising results in understanding BBB dysfunction in Alzheimer's, indicating that this approach has potential for significant findings.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LU, HANZHANG — JOHNS HOPKINS UNIVERSITY
- Study coordinator: LU, HANZHANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome