Investigating blood-brain barrier dysfunction in patients with post-stroke dementia
BBB dysfunction in post-stroke dementia
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-10911182
This study is looking at how problems with the blood-brain barrier might affect thinking and memory in people who have had a stroke, and it’s for stroke survivors who want to help us understand more about post-stroke dementia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10911182 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how blood-brain barrier dysfunction contributes to cognitive decline in individuals who have experienced a stroke. It aims to identify inflammation-induced changes in blood vessels that may lead to leakage in the blood-brain barrier, which could be a key factor in post-stroke dementia. The study will involve recruiting 200 chronic stroke survivors and 50 control participants across three sites, utilizing MRI imaging to assess blood-brain barrier permeability. By exploring these mechanisms, the research seeks to uncover potential biomarkers for predicting cognitive decline in stroke patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a stroke and are at risk of cognitive decline or dementia.
Not a fit: Patients who have not had a stroke or do not exhibit signs of cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new methods for identifying individuals at risk of dementia after a stroke, enabling earlier interventions.
How similar studies have performed: Previous research has indicated that neuroinflammation and blood-brain barrier dysfunction are critical factors in post-stroke cognitive decline, suggesting that this approach has the potential for significant insights.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BUCKWALTER, MARION S — STANFORD UNIVERSITY
- Study coordinator: BUCKWALTER, MARION S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.