Investigating blood biomarkers of Alzheimer's disease in middle-aged individuals of African ancestry
Myosteatosis, Cognition, and Blood Biomarkers of Alzheimer's Disease in Persons of African Ancestry
This study is looking at blood samples from men and women of African ancestry aged 45-65 to see how differences between the sexes and certain body factors affect Alzheimer's disease markers, with the goal of finding ways to lower the risk of Alzheimer's as people get older.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10942739 on NIH RePORTER |
What this research studies
This research focuses on measuring and comparing blood levels of Alzheimer's disease (AD) biomarkers in men and women of African ancestry aged 45-65. It aims to understand how sex differences and factors like adipo-myokines influence these biomarker levels. By examining these relationships, the study seeks to identify when disparities in AD pathology begin and how mid-life interventions could potentially reduce these risks. Participants will undergo blood tests to assess their AD biomarkers and related inflammatory markers.
Who could benefit from this research
Good fit: Ideal candidates for this research are men and women of African ancestry aged 45-65.
Not a fit: Patients outside the age range of 45-65 or those not of African ancestry may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted interventions that reduce the risk of Alzheimer's disease in middle-aged individuals of African ancestry.
How similar studies have performed: Other research has shown success in identifying sex differences in Alzheimer's disease biomarkers, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Miljkovic, Iva — University of Pittsburgh at Pittsburgh
- Study coordinator: Miljkovic, Iva
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.