Investigating blood-based markers for Alzheimer's disease risk in veterans

Who could benefit from this research

What this research studies

This research focuses on understanding how changes in DNA methylation in the blood can indicate the risk of Alzheimer's disease and related dementias (ADRD) among veterans aged 65 and older. By analyzing data from the Million Veteran Program, the study aims to identify specific DNA markers that could lead to the development of simple blood tests for diagnosing and monitoring ADRD. The approach is less invasive and more cost-effective compared to current diagnostic methods, which often involve expensive imaging techniques. Ultimately, the goal is to improve early detection and treatment tracking for those at risk or diagnosed with ADRD.

Why it matters

Where this research is happening

• VA Boston Health Care System
  Boston, United States Active

Researchers

• Principal investigator: Miller, Mark W — VA Boston Health Care System
• Study coordinator: Miller, Mark W

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.