Investigating blood and vascular cell biology for potential therapies
Basic Investigation and Translational Applications Concerning the Cell and Molecular Biology of Blood and Vascular Cells
This study is looking at a special protein called PECAM-1 to see how it affects blood vessel health, with the hope of finding new ways to help babies with low platelet counts and improve treatments for conditions like sepsis and poor blood flow.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Versiti Wisconsin, INC. NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10831497 on NIH RePORTER |
What this research studies
This research focuses on understanding the cell and molecular biology of blood and vascular cells, particularly the role of PECAM-1 in vascular function and the pathophysiology of neonatal alloimmune thrombocytopenia. The researchers will utilize advanced tools and animal models to explore how PECAM-1 can be targeted to improve vascular permeability and address conditions like sepsis and ischemia. By examining the structure and function of PECAM-1, the study aims to uncover new therapeutic strategies for various blood and vascular disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with coagulation disorders, bleeding disorders, or conditions affecting vascular function.
Not a fit: Patients with non-vascular related conditions or those not affected by blood cell dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for conditions related to blood and vascular cell dysfunction.
How similar studies have performed: Previous research has shown promise in targeting PECAM-1 for therapeutic applications, indicating potential for success in this area.
Where this research is happening
Milwaukee, United States
- Versiti Wisconsin, INC. — Milwaukee, United States (Active)
Researchers
- Principal investigator: Newman, Peter J — Versiti Wisconsin, INC.
- Study coordinator: Newman, Peter J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.