Investigating bladder sensory nerves and their cell types using advanced sequencing techniques
Translational profiling of bladder sensory nerves and their cell type identities using dissociation free single nucleus sequencing
['FUNDING_R21'] · WASHINGTON UNIVERSITY · NIH-10456999
This study is looking at how the nerves in your bladder work and stay connected over time, aiming to find out which genes are active in these nerves when you're healthy or dealing with bladder issues, so we can better understand bladder disorders and how they affect you.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10456999 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how bladder sensory nerves function and maintain their connections throughout a person's life. By using a technique called dissociation-free single nucleus sequencing, the researchers aim to identify the specific genes that are actively translated in these nerves under both healthy and disease conditions. This approach will help uncover how bladder nerves interact with various cell types and respond to changes or injuries. The findings could provide valuable insights into bladder disorders and their underlying mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing bladder disorders or related symptoms.
Not a fit: Patients with non-bladder related neurological conditions or those under 21 years old may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bladder disorders by enhancing our understanding of nerve function and repair.
How similar studies have performed: While the specific approach of using dissociation-free single nucleus sequencing for bladder nerves is relatively novel, similar techniques have shown promise in other areas of neuroscience and may indicate potential success.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JAIN, SANJAY — WASHINGTON UNIVERSITY
- Study coordinator: JAIN, SANJAY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.