Investigating bladder function issues related to aging
Detrusor Underactivity as an HCN-mediated Failure of Resilience in Aging
['FUNDING_R01'] · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · NIH-10556327
This study is looking at how aging affects bladder function in older adults who have trouble emptying their bladders, and it aims to find new ways to help improve bladder health for them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CONNECTICUT SCH OF MED/DNT (nih funded) |
| Locations | 1 site (FARMINGTON, UNITED STATES) |
| Trial ID | NIH-10556327 on ClinicalTrials.gov |
What this research studies
This research focuses on Detrusor Underactivity (DU), a condition where the bladder muscle does not contract effectively, leading to difficulties in emptying the bladder, particularly in older adults. The study aims to understand how aging affects bladder sensitivity and resilience, which are crucial for proper bladder function. By using advanced techniques such as single cell genomic sequencing and electrophysiology, researchers will explore the underlying mechanisms of DU and its relationship with aging. The findings could help identify new ways to improve bladder health in older individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing bladder control issues or urinary symptoms.
Not a fit: Patients who are younger and do not have any bladder function problems are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management and treatment options for bladder issues in older adults, improving their quality of life.
How similar studies have performed: Previous research has shown promising results in understanding bladder function and aging, suggesting that this approach could yield valuable insights.
Where this research is happening
FARMINGTON, UNITED STATES
- UNIVERSITY OF CONNECTICUT SCH OF MED/DNT — FARMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KUCHEL, GEORGE A — UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
- Study coordinator: KUCHEL, GEORGE A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.