Investigating biomarkers to understand postoperative delirium and cognitive decline
Examining CSF and Blood Biomarkers to Gain Insight into Postoperative Delirium and Neurocognitive Dysfunction
This study is looking at certain markers in your blood and spinal fluid to understand why some people experience confusion or memory problems after surgery, especially those at risk for Alzheimer's, so we can learn how surgery might affect your brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11023963 on NIH RePORTER |
What this research studies
This research examines the role of specific biomarkers found in cerebrospinal fluid (CSF) and blood to uncover the causes of postoperative delirium and neurocognitive dysfunction that can occur after surgery. By analyzing these biomarkers, the study aims to identify pathways that lead to cognitive decline, particularly in patients at risk for conditions like Alzheimer's Disease. The approach includes collecting and analyzing serial measurements of CSF and blood samples from patients during and after their surgical procedures. This could help in understanding how surgical interventions might impact brain health and cognitive function over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals scheduled for surgery who may be at risk for postoperative delirium or cognitive dysfunction.
Not a fit: Patients who are not undergoing surgery or those without risk factors for cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cognitive decline in patients undergoing surgery.
How similar studies have performed: Previous research has shown promise in using biomarkers to understand Alzheimer's Disease, suggesting that this approach could yield valuable insights into postoperative cognitive issues as well.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Brown, Charles Hugh — Stanford University
- Study coordinator: Brown, Charles Hugh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.