Investigating biomarkers for REM sleep behavior disorder related to neurodegenerative diseases
NAPS2 Biofluid Core
This study is looking at REM sleep behavior disorder to find helpful markers in blood and spinal fluid that can show how the condition progresses and how well treatments are working, which could lead to better ways to diagnose and treat people with this disorder and related diseases like Parkinson's and dementia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10866376 on NIH RePORTER |
What this research studies
This research focuses on REM sleep behavior disorder (RBD), which often precedes neurodegenerative diseases like Parkinson's and dementia. The project aims to collect and analyze biofluids, such as plasma and cerebrospinal fluid, to identify biomarkers that can indicate disease progression and efficacy of treatments. By coordinating with various consortium sites, the research will perform assays on established neurodegenerative markers and develop new ones to enhance clinical trial efficiency. Patients may benefit from improved diagnostic tools and treatment strategies based on these biomarkers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with REM sleep behavior disorder, particularly those at risk for Parkinson's disease or related dementias.
Not a fit: Patients without REM sleep behavior disorder or those not at risk for neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better management of neurodegenerative diseases for patients.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Kotzbauer, Paul T — Washington University
- Study coordinator: Kotzbauer, Paul T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.