Investigating biomarkers for cognitive decline before dementia onset
Official title: Longitudinal multi-omic biomarkers for neurocognitive decline prior to dementia onset
Funded at University of Edinburgh · NIH-10884528 · Data updated 2026-11-12
This study is looking for certain proteins in the body that might show if someone is starting to have memory problems before they get diagnosed with Alzheimer's or similar conditions, helping to find ways to catch these issues earlier and support those at risk.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Edinburgh NIH-funded |
| Lab location | 1 site (Edinburgh, United Kingdom) |
| Project start | September 30, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,311,409 |
| NIH project number | 1U01AG083829-01A1 |
| Project ID | NIH-10884528 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who may be experiencing early signs of cognitive decline.
✕Less likely to help
Patients who are younger than 65 or those who do not exhibit any cognitive decline may not benefit from this research.
What this research studies
This research focuses on identifying specific protein biomarkers that can indicate cognitive decline and brain changes in individuals before they are diagnosed with Alzheimer's Disease and related dementias. By analyzing data from a large longitudinal study, researchers will measure thousands of proteins at different ages to understand their relationship with cognitive health. The study aims to uncover molecular processes that contribute to dementia, potentially leading to earlier detection and intervention strategies for at-risk individuals.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better management of Alzheimer's Disease and related dementias.
How similar studies have gone: Previous research has shown promise in identifying biomarkers for cognitive decline, making this approach a continuation of successful methodologies.
Where this research is happening
-
University of Edinburgh
Edinburgh, United Kingdom Active
Researchers
- Principal investigator: Harris, Sarah Elizabeth — University of Edinburgh
- Study coordinator: Harris, Sarah Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.