Investigating biomarkers for chronic obstructive pulmonary disease (COPD)
Official title: Patient oriented research and mentoring in COPD biomarker studies
Funded at Brigham and Women's Hospital · NIH-11051504 · Data updated 2026-11-12
This study is looking for special markers in the blood and lung fluid of people with COPD to better understand how the disease changes over time and how well treatments work, all while helping doctors learn more about this important research.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $131,783 |
| NIH project number | 1K24HL173667-01A1 |
| Project ID | NIH-11051504 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic obstructive pulmonary disease (COPD), particularly those experiencing frequent exacerbations or rapid declines in lung function.
✕Less likely to help
Patients with stable COPD who do not experience exacerbations or those with other unrelated respiratory conditions may not benefit from this research.
What this research studies
This research focuses on chronic obstructive pulmonary disease (COPD), a complex condition that varies significantly among patients. It aims to identify specific biomarkers that can indicate disease progression, acute exacerbations, and responses to treatment, thereby enhancing personalized medicine approaches. The study will involve collecting blood and bronchoalveolar lavage fluid samples from patients undergoing bronchoscopy procedures, and will utilize advanced techniques like RNA-sequencing to analyze these samples. Additionally, the project emphasizes training physician-scientists in the necessary skills for conducting large-scale genetic epidemiology studies.
Why it matters
Potential benefit: If successful, this research could lead to more precise and effective treatments for COPD patients based on their unique disease characteristics.
How similar studies have gone: Previous research has shown promise in identifying biomarkers for COPD, suggesting that this approach could yield valuable insights and advancements in treatment.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Hersh, Craig P — Brigham and Women's Hospital
- Study coordinator: Hersh, Craig P
Related research
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-
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-
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-
Next-Generation Wearable AI for Precision COPD Risk and Care
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-
Ethics-aware Multimodal AI for COPD prevention, diagnosis, and treatment
A broad AI model uses diverse health data to help predict and manage COPD in people, with an emphasis on ethics and fairness.
-
Easier, local pulmonary rehab and social support for people with COPD in low-resource clinics
This project compares a 10-week community pulmonary rehabilitation program alone, the same program plus help with social needs, and usual care for people with moderate-to-severe COPD to see which helps people stick with rehab and feel better.
-
Improving COPD outcomes with real-world data
A doctor-scientist at a major university is using real-world information from COPD patients to understand which treatments work best, how safe they are, and whether people stick to their inhaler plans.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.