Investigating biomarkers for brain health in older adults without dementia
Longitudinal validation of cerebral small vessel disease biomarkers in diverse community-based older adults without dementia
This study is looking for signs in the brain that can help us understand how small vessel disease affects thinking and memory in older adults who don’t have dementia, and we’re inviting community members to join us in this important research!
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10923802 on NIH RePORTER |
What this research studies
This research focuses on identifying and validating biomarkers related to cerebral small vessel disease (SVD) in older adults who do not have dementia. By recruiting a diverse group of community-based participants, the study aims to assess how these biomarkers correlate with brain health and cognitive function over time. Participants will undergo clinical evaluations and assessments to track changes and associations with SVD. The goal is to enhance understanding of SVD and its impact on cognition, ultimately aiding in diagnosis and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults from diverse backgrounds who are free of dementia.
Not a fit: Patients with existing dementia or severe cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for diagnosing and preventing cognitive decline related to small vessel disease.
How similar studies have performed: Previous research has shown promise in using biomarkers for understanding cerebral small vessel disease, indicating potential for success in this approach.
Where this research is happening
Chicago, United States
- Rush University Medical Center — Chicago, United States (Active)
Researchers
- Principal investigator: Arfanakis, Konstantinos — Rush University Medical Center
- Study coordinator: Arfanakis, Konstantinos
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.