Investigating biomarkers and cellular models for early-stage kidney disease
Biomedical Research Core 1 - Biomarkers, Biomaterials, and Cellular Models Core
['FUNDING_OTHER'] · UNIVERSITY OF KANSAS MEDICAL CENTER · NIH-10884894
This study is looking for helpful signs in blood and urine from people with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and their siblings to improve how we diagnose and monitor the condition, and to find better treatment options.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS MEDICAL CENTER (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-10884894 on ClinicalTrials.gov |
What this research studies
This research focuses on identifying and analyzing biomarkers related to early-stage Autosomal Dominant Polycystic Kidney Disease (ADPKD) using human biospecimens. The project involves collecting serum, plasma, urine, and urinary exosomes from individuals with ADPKD and at-risk siblings, which are then used to discover effective biomarkers for diagnosis and monitoring. The research also includes in-house analysis of these samples to support the evaluation of potential therapeutic interventions. By maintaining a comprehensive repository of biospecimens, the project aims to enhance the understanding of ADPKD progression and treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with early-stage ADPKD and their at-risk siblings.
Not a fit: Patients with advanced-stage ADPKD or those without a family history of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of sensitive biomarkers that improve the diagnosis and monitoring of early-stage ADPKD, potentially leading to better treatment outcomes.
How similar studies have performed: Other research has shown success in identifying biomarkers for various kidney diseases, indicating that this approach has the potential for meaningful advancements.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF KANSAS MEDICAL CENTER — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WALLACE, DARREN P. — UNIVERSITY OF KANSAS MEDICAL CENTER
- Study coordinator: WALLACE, DARREN P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult Polycystic Kidney Disease, Autosomal Dominant Polycystic Kidney Disease