Investigating biomarkers and biology of early-stage heart failure
Official title: Integrative 'omics for biomarkers and biology of early-stage heart failure
Funded at Duke University · NIH-10994115 · Data updated 2026-11-12
This study is looking at early-stage heart failure to find new ways to tell it apart from more advanced stages, with the hope of discovering helpful tests and treatments that can improve care for people with this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31HL175914-01 |
| Project ID | NIH-10994115 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have been diagnosed with early-stage heart failure or exhibit signs of asymptomatic structural heart disease.
✕Less likely to help
Patients with advanced heart failure or those without any signs of heart disease may not benefit from this research.
What this research studies
This research focuses on understanding early-stage heart failure, which is characterized by asymptomatic structural heart disease. The study aims to identify novel biomarkers and biological mechanisms that differentiate early-stage heart failure from advanced heart failure and its risk factors. By utilizing integrative -omics techniques, the research seeks to uncover molecular features related to cardiac inflammation that could serve as significant biomarkers. The ultimate goal is to develop diagnostic tests and preemptive treatments to improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better management of heart failure, potentially preventing its progression to more severe stages.
How similar studies have gone: Previous research has shown promise in using -omics approaches to identify biomarkers in advanced heart failure, suggesting potential for success in this novel application.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Kottilil, Kalyani — Duke University
- Study coordinator: Kottilil, Kalyani
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.