Investigating bile acids and a specific signaling molecule in liver disease
Bile Acids and Sphingosine 1-Phosphate in Non-Alcoholic Steatohepatitis (NASH)
['FUNDING_OTHER'] · VA VETERANS ADMINISTRATION HOSPITAL · NIH-10950309
This study is looking at how certain substances in the body, like bile acids and sphingosine-1-phosphate, influence the worsening of non-alcoholic steatohepatitis (NASH), a serious liver condition, to help find new ways to treat it for people living with this disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VA VETERANS ADMINISTRATION HOSPITAL (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-10950309 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of bile acids and sphingosine-1-phosphate in the progression of non-alcoholic steatohepatitis (NASH), a severe form of liver disease. The study aims to explore how these molecules affect liver metabolism and immune responses, which could lead to new therapeutic strategies. By examining the pathways involved in liver disease progression, the research seeks to identify potential targets for treatment. Patients with NASH may benefit from insights gained through this research, which could inform future therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-alcoholic steatohepatitis or those at risk of developing liver disease due to metabolic syndrome.
Not a fit: Patients with alcoholic liver disease or other liver conditions unrelated to non-alcoholic fatty liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from non-alcoholic steatohepatitis and related liver diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of bile acids in liver disease, suggesting that this approach could yield valuable insights.
Where this research is happening
RICHMOND, UNITED STATES
- VA VETERANS ADMINISTRATION HOSPITAL — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHOU, HUIPING ROSE — VA VETERANS ADMINISTRATION HOSPITAL
- Study coordinator: ZHOU, HUIPING ROSE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.