Investigating B cells that respond to kidney transplant donors.
Donor-specific B cells in Transplantation.
This study is looking at how certain immune cells called B cells in kidney transplant patients create antibodies against the donor's kidney, which can help us understand why some transplants are accepted while others are rejected, with the hope of finding better treatments to improve transplant success.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11270062 on NIH RePORTER |
What this research studies
This research focuses on understanding how B cells in kidney transplant recipients generate antibodies specific to the transplant donor. By analyzing the characteristics of these donor-specific B cells, the study aims to identify factors that contribute to either the rejection of the transplant or its successful acceptance. The researchers will use advanced techniques like single-cell sequencing and RNA sequencing to explore the genetic and functional properties of these B cells. This knowledge could lead to new therapies that target B cell responses to improve transplant outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received a kidney transplant and are experiencing or at risk of antibody-mediated rejection.
Not a fit: Patients who have not undergone kidney transplantation or those with other types of organ transplants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing transplant rejection and enhancing graft survival.
How similar studies have performed: Previous research has shown that understanding B cell responses can significantly impact transplant outcomes, indicating that this approach has potential for success.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Cascalho, Marilia Isabel — Case Western Reserve University
- Study coordinator: Cascalho, Marilia Isabel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.