Investigating autoimmune causes of kidney diseases related to podocytes
Official title: Pathobiology of autoimmune-mediated diffuse podocytopathy
Funded at Brigham and Women's Hospital · NIH-11184383 · Data updated 2026-11-12
This study is looking at how certain antibodies in the body might affect kidney diseases like minimal change disease and focal segmental glomerulosclerosis, especially for people dealing with nephrotic syndrome, to help find better treatments for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 5, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $708,681 |
| NIH project number | 5R01DK135667-02 |
| Project ID | NIH-11184383 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with minimal change disease or focal segmental glomerulosclerosis, particularly those experiencing nephrotic syndrome.
✕Less likely to help
Patients with kidney diseases not related to autoimmune mechanisms may not benefit from this research.
What this research studies
This research focuses on understanding the role of autoantibodies in kidney diseases characterized by podocyte damage, specifically minimal change disease and focal segmental glomerulosclerosis. The study aims to establish a link between these autoantibodies and the disease's progression, particularly in patients experiencing nephrotic syndrome. By analyzing immune profiles and the effects of these antibodies on kidney cells, the research seeks to uncover the underlying mechanisms that lead to kidney dysfunction. This could provide insights into more effective treatments for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for patients suffering from autoimmune-related kidney diseases.
How similar studies have gone: Previous studies have shown promising results in understanding autoimmune mechanisms in kidney diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Weins, Astrid — Brigham and Women's Hospital
- Study coordinator: Weins, Astrid
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.