Investigating autism risk genes using zebrafish models
High-throughput modeling of autism risk genes using zebrafish
This study is looking at how certain inherited genes might play a role in autism spectrum disorder by using zebrafish to see how these genes affect brain development and behavior, making it easier and cheaper to test different genetic changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-10910073 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic factors that contribute to autism spectrum disorder (ASD) by using zebrafish as a model organism. The team aims to identify and explore the effects of various inherited genetic variations linked to ASD, which have been less studied compared to de novo mutations. By leveraging the unique advantages of zebrafish, such as their rapid development and transparent bodies, researchers will assess how these genetic factors influence neurodevelopment and behavior. This approach allows for efficient screening and testing of multiple genetic mutations in a cost-effective manner.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of autism or those diagnosed with autism spectrum disorder.
Not a fit: Patients who do not have a genetic predisposition to autism or who are not diagnosed with ASD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic underpinnings of autism, potentially paving the way for new therapeutic strategies.
How similar studies have performed: Previous research using zebrafish models has shown promise in understanding genetic contributions to various disorders, indicating that this approach could yield valuable insights for autism as well.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Prober, David Aaron — California Institute of Technology
- Study coordinator: Prober, David Aaron
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.