Investigating asthma prevention in urban children
District of Columbia Childhood Asthma in Urban Settings - Clinical Research Center
This study is looking at how a single dose of an asthma medication called omalizumab can help prevent asthma attacks in urban kids, especially those from less advantaged backgrounds, during the fall, while also exploring how germs in the nose and inflammation play a role during viral infections that can trigger asthma.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11058358 on NIH RePORTER |
What this research studies
This research focuses on understanding and preventing asthma exacerbations in urban youth, particularly those from disadvantaged backgrounds. It involves a multi-disciplinary team that will explore the effects of a single dose of omalizumab, an anti-IgE medication, during the fall season to see if it can prevent asthma attacks. The study will also look at how the nasal microbiome and inflammatory responses interact during viral infections, which are common triggers for asthma exacerbations. By leveraging a large population of urban children with asthma, the research aims to provide valuable insights into effective prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are urban children aged 0-11 years who have a history of asthma or are at risk for asthma exacerbations.
Not a fit: Patients who do not have asthma or are outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved asthma management and prevention strategies for children living in urban environments.
How similar studies have performed: Previous research has shown promise in using anti-IgE therapies for asthma management, indicating that this approach may yield beneficial results.
Where this research is happening
Washington, United States
- Children's Research Institute — Washington, United States (Active)
Researchers
- Principal investigator: Sheehan, William James — Children's Research Institute
- Study coordinator: Sheehan, William James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.