Investigating arthritis caused by cancer immunotherapy
Official title: Understanding Inflammatory Arthritis due to Immune Checkpoint Inhibitors
Funded at Johns Hopkins University · NIH-10680524 · Data updated 2026-11-12
This study is looking at how some cancer treatments can cause joint pain and swelling in certain patients, and it aims to find out what makes some people more likely to experience this so we can improve care for those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 16, 2019 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $155,814 |
| NIH project number | 5K23AR075872-05 |
| Project ID | NIH-10680524 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have received immune checkpoint inhibitors and developed inflammatory arthritis.
✕Less likely to help
Patients who have not undergone treatment with immune checkpoint inhibitors or do not have inflammatory arthritis may not benefit from this research.
What this research studies
This research focuses on understanding inflammatory arthritis that can occur as a side effect of immune checkpoint inhibitors, which are used in cancer treatment. By studying a group of patients who have developed this type of arthritis and comparing them to those who have not, the research aims to identify the clinical characteristics and risk factors associated with this condition. The project will analyze patient data, including serum cytokine profiles and autoantibodies, to uncover important insights that could lead to better monitoring and treatment strategies for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment options for patients experiencing arthritis due to cancer immunotherapy.
How similar studies have gone: Other research has shown promising results in understanding immune-related adverse events from cancer therapies, indicating that this approach has potential for success.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Cappelli, Laura Christine — Johns Hopkins University
- Study coordinator: Cappelli, Laura Christine
Related research
Other NIH-funded projects on the same topics.
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Understanding how immune checkpoint drugs can trigger inflammatory arthritis in cancer patients
This research looks at why some cancer patients develop inflammatory arthritis after PD-1 inhibitor therapy and what could be done to prevent it.
-
Antenatal DMARD Use and Mother-Child Health in Women with Chronic Inflammatory Arthritis
This project aims to understand how continuing pregnancy-safe arthritis medicines during pregnancy affects health outcomes for mothers with chronic inflammatory arthritis and their babies.
-
Gut barrier and antibiotics: how gut health affects inflammatory arthritis
Antibiotic use may increase the risk of inflammatory arthritis by changing the gut, and this project looks at how those gut changes influence joint inflammation in people with arthritis.
-
ctDNA biomarker to guide safety of cancer immunotherapy in inflammatory arthritis
A patient-facing biomarker study using a blood test to detect tumor DNA in people with cancer who develop inflammatory arthritis from immunotherapy, to help doctors pick safer treatment choices.
-
Setbp1’s role in how joint cells behave during inflammatory arthritis
This project looks at how a protein called SETBP1 affects delicate joint cells (FLS) that drive inflammation in arthritis, with potential implications for better treatments.
-
Bacteria-made indoles and inflammatory arthritis
A study from the University of Colorado Denver is looking at how gut bacteria convert tryptophan into indoles that may drive inflammatory arthritis in people.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.