Investigating arthritis caused by cancer immunotherapy
Understanding Inflammatory Arthritis due to Immune Checkpoint Inhibitors
This study is looking at how some cancer treatments can cause joint pain and swelling in certain patients, and it aims to find out what makes some people more likely to experience this so we can improve care for those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10680524 on NIH RePORTER |
What this research studies
This research focuses on understanding inflammatory arthritis that can occur as a side effect of immune checkpoint inhibitors, which are used in cancer treatment. By studying a group of patients who have developed this type of arthritis and comparing them to those who have not, the research aims to identify the clinical characteristics and risk factors associated with this condition. The project will analyze patient data, including serum cytokine profiles and autoantibodies, to uncover important insights that could lead to better monitoring and treatment strategies for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have received immune checkpoint inhibitors and developed inflammatory arthritis.
Not a fit: Patients who have not undergone treatment with immune checkpoint inhibitors or do not have inflammatory arthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment options for patients experiencing arthritis due to cancer immunotherapy.
How similar studies have performed: Other research has shown promising results in understanding immune-related adverse events from cancer therapies, indicating that this approach has potential for success.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Cappelli, Laura Christine — Johns Hopkins University
- Study coordinator: Cappelli, Laura Christine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.