Investigating antigens for vaccines against Valley Fever
Early in vivo expressed antigens and their role in virulence, immune response, and vaccines for coccidioidomycosis
This study is looking into how certain proteins related to Valley Fever can help create a safe and effective vaccine, using animal tests to see how well these new vaccines can boost the immune system, which could eventually protect people from this growing disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern Arizona University NIH-funded |
| Lab location | 1 site (Flagstaff, United States) |
| Project ID | NIH-10899660 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of early expressed antigens in the disease coccidioidomycosis, commonly known as Valley Fever. It aims to develop a safe and effective vaccine by exploring nucleic acid vaccines, such as DNA and RNA, which can induce strong immune responses without the risks associated with live infections. The study will utilize animal models to assess the immune response and virulence of these antigens, providing insights that could lead to a viable vaccine for humans. Patients may benefit from advancements in vaccine development that could protect against this increasingly prevalent disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals living in arid regions who are at risk for Valley Fever.
Not a fit: Patients who do not reside in areas where Valley Fever is prevalent may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of a safe and effective vaccine for Valley Fever, significantly reducing the incidence of the disease.
How similar studies have performed: Previous research has shown promise in using nucleic acid vaccines for other diseases, indicating potential success for this novel approach in developing a vaccine for Valley Fever.
Where this research is happening
Flagstaff, United States
- Northern Arizona University — Flagstaff, United States (Active)
Researchers
- Principal investigator: Fuller, Deborah H. — Northern Arizona University
- Study coordinator: Fuller, Deborah H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.