Investigating antifungal resistance in coccidioidomycosis
Official title: Relationship between in vitro antifungal resistance and in vivo response in coccidioidomycosis
Funded at University of Texas San Antonio · NIH-11004664 · Data updated 2026-11-12
This study is looking at how some strains of a serious fungal infection called coccidioidomycosis resist antifungal medications, and it aims to find better treatment options for patients, especially those with lung or brain issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas San Antonio NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $271,400 |
| NIH project number | 5U19AI166761-04 |
| Project ID | NIH-11004664 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients diagnosed with coccidioidomycosis, particularly those experiencing severe or resistant forms of the infection.
✕Less likely to help
Patients with mild coccidioidomycosis who respond well to standard antifungal treatments may not benefit from this research.
What this research studies
This research focuses on understanding how resistance to antifungal medications affects the treatment of coccidioidomycosis, a serious fungal infection. Researchers will study the effectiveness of different antifungal drugs in both laboratory settings and animal models to see how well they work against resistant strains of the fungus. The goal is to provide insights that could lead to better treatment options for patients suffering from this infection, particularly those with central nervous system and pulmonary involvement.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with coccidioidomycosis, especially those with drug-resistant infections.
How similar studies have gone: Previous research has indicated that understanding antifungal resistance can significantly impact treatment outcomes, suggesting that this approach has potential for success.
Where this research is happening
-
University of Texas San Antonio
San Antonio, United States Active
Researchers
- Principal investigator: Patterson, Thomas F. — University of Texas San Antonio
- Study coordinator: Patterson, Thomas F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.