Investigating anticoagulant use for preventing blood clots in patients with inflammatory bowel disease
Official title: Anticoagulant use, safety, and effectiveness for venous thromboembolism prevention in inflammatory bowel disease patients
Funded at Vanderbilt University Medical Center · NIH-10893637 · Data updated 2026-11-12
This study is looking at how well blood-thinning medications can help prevent blood clots in people with inflammatory bowel disease, both when they're in the hospital and at home, while also making sure these treatments are safe for those who might be at higher risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL159230-04 |
| Project ID | NIH-10893637 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease who may be at risk for developing venous thromboembolism.
✕Less likely to help
Patients with conditions unrelated to inflammatory bowel disease or those who do not have a risk of venous thromboembolism may not benefit from this research.
What this research studies
This research focuses on improving the prevention and treatment of venous thromboembolism (VTE) in patients with inflammatory bowel disease (IBD). It aims to evaluate the effectiveness and safety of anticoagulants in both inpatient and outpatient settings, addressing the barriers that prevent their use in this population. The study will gather data on anticoagulant use, assess the risks of bleeding complications, and explore the safety of these medications in high-risk groups, such as those experiencing disease flares. By analyzing existing health records and conducting targeted assessments, the research seeks to provide evidence that can guide clinical practice for IBD patients.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for blood clots in IBD patients, potentially reducing morbidity and mortality associated with VTE.
How similar studies have gone: While there has been some research on anticoagulant use in general populations, this specific focus on IBD patients is relatively novel and aims to fill significant gaps in existing literature.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Dawwas, Ghadeer K. — Vanderbilt University Medical Center
- Study coordinator: Dawwas, Ghadeer K.
Related research
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A large clinical trial will test whether taking rosuvastatin daily for a year helps prevent dangerous blood clots in people with newly diagnosed or relapsed cancer who aren’t already getting anticoagulants.
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A Johns Hopkins-led study is exploring how a human gene, BCOR, may control liver-produced clotting factors to influence venous blood clots.
-
Personalized risk-prediction for hospital-acquired blood clots in adults
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.