Investigating antibody-mediated blood disorders and their underlying mechanisms
Official title: Protein Production, Structural Biology, and Nucleic Acid Sequencing and Analysis
Funded at Versiti Wisconsin, INC. · NIH-10934142 · Data updated 2026-11-12
This study is looking at how certain antibodies can cause blood disorders by affecting platelets, and it's aimed at helping people with autoimmune thrombocytopenias by finding better treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Versiti Wisconsin, INC. NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $412,500 |
| NIH project number | 1P01HL167668-01A1 |
| Project ID | NIH-10934142 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autoimmune thrombocytopenias or related blood disorders.
✕Less likely to help
Patients with non-autoimmune related blood disorders or those not affected by antibody-mediated conditions may not benefit from this research.
What this research studies
This research focuses on understanding specific blood disorders caused by antibodies that affect platelet function. It utilizes advanced techniques such as protein production, structural biology, and next-generation sequencing to analyze how certain antibodies interact with blood components. By studying the mechanisms behind the formation of these antibodies, the research aims to uncover insights that could lead to better treatments for patients suffering from autoimmune thrombocytopenias. The project also emphasizes the importance of standardized methods to ensure reliable and reproducible results.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for patients with autoimmune blood disorders.
How similar studies have gone: Previous research has shown promise in understanding antibody-mediated conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Versiti Wisconsin, INC.
Milwaukee, United States Active
Researchers
- Principal investigator: Zhu, Jieqing — Versiti Wisconsin, INC.
- Study coordinator: Zhu, Jieqing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.