Investigating antibodies that protect against Influenza Type B Virus
Official title: Discovery and characterization of protective Influenza Type B Virus neuraminidase antibodies
Funded at Oregon Health & Science University · NIH-11163147 · Data updated 2026-11-12
This study is looking at how special antibodies from people who have had the flu can help treat and prevent Influenza Type B, using a new way to deliver them right where the virus grows, and it's also helping the researcher learn to run their own lab.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | August 7, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $122,850 |
| NIH project number | 7K01OD036063-02 |
| Project ID | NIH-11163147 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of Influenza Type B infection or those at high risk for severe influenza complications.
✕Less likely to help
Patients who have not been infected with Influenza Type B or those with other unrelated respiratory conditions may not benefit from this research.
What this research studies
This research focuses on understanding how human antibodies against the Influenza Type B Virus can be used to treat and prevent the disease. The approach involves isolating and characterizing monoclonal antibodies from individuals who have previously had influenza, and testing their effectiveness in animal models. A novel delivery method aims to apply these antibodies directly to the respiratory mucosal surface, where the virus replicates, potentially improving treatment outcomes. The project will also provide training for the principal investigator to establish an independent research laboratory.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Influenza Type B, particularly for vulnerable populations.
How similar studies have gone: Previous research has shown promise in using monoclonal antibodies for treating viral infections, indicating potential success for this novel approach.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Wolters, Rachael — Oregon Health & Science University
- Study coordinator: Wolters, Rachael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.