Investigating antibodies linked to rapid-onset OCD in children
Anti-interneuron antibodies in rapid-onset pediatric OCD: clinical generalization and target identification
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10880385
This study is looking at how certain antibodies in children might cause sudden obsessive-compulsive disorder (OCD) after infections, and by testing blood samples, researchers hope to find out how these antibodies affect the brain and improve treatment options for kids with OCD.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10880385 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how certain antibodies may trigger rapid-onset obsessive-compulsive disorder (OCD) in children, particularly following infections. It explores the role of autoantibodies that may bind to specific brain cells, leading to inflammation and OCD symptoms. By examining blood samples from affected children, the study aims to identify the targets of these antibodies and their impact on brain function. This could help clarify the underlying mechanisms of this condition and improve treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have experienced a rapid onset of OCD symptoms, particularly following an infectious illness.
Not a fit: Patients who do not have rapid-onset OCD or those whose symptoms are not linked to infectious triggers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted therapies for children suffering from rapid-onset OCD.
How similar studies have performed: Previous research has shown promising results in understanding the role of autoantibodies in neuropsychiatric disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PITTENGER, CHRISTOPHER JOHN — YALE UNIVERSITY
- Study coordinator: PITTENGER, CHRISTOPHER JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.