Investigating amino acids for treating liver fat in children
Official title: Amino Acids and Pediatric Hepatic Steatosis
Funded at Amino Company LLC, the · NIH-10931666 · Data updated 2026-11-12
This study is looking at how well a special amino acid treatment called AMS2392 can help reduce liver fat in kids with non-alcoholic fatty liver disease, and it will compare the results over eight weeks to see if it really makes a difference.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Amino Company LLC, the NIH-funded |
| Lab location | 1 site (Lewes, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $860,498 |
| NIH project number | 5R44DK135312-02 |
| Project ID | NIH-10931666 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents aged 0-17 years who have been diagnosed with hepatic steatosis.
✕Less likely to help
Patients who do not have hepatic steatosis or those with other liver diseases unrelated to NAFLD may not benefit from this research.
What this research studies
This research focuses on non-alcoholic fatty liver disease (NAFLD), which is the most common liver disease in North America, particularly affecting children. The study aims to evaluate the effectiveness of an essential amino acid-based treatment called AMS2392 in reducing liver fat in youths diagnosed with hepatic steatosis. By conducting a randomized clinical trial, the researchers will compare the effects of this treatment over eight weeks in a controlled environment, ensuring that neither the participants nor the researchers know who receives the treatment or a placebo. This approach aims to provide robust evidence on the potential benefits of amino acids in managing liver health in children.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment option for reducing liver fat in children, potentially improving their long-term metabolic and cardiovascular health.
How similar studies have gone: Previous studies have shown success in using amino acid-based treatments for related conditions, indicating potential for this approach in pediatric hepatic steatosis.
Where this research is happening
-
Amino Company LLC, the
Lewes, United States Active
Researchers
- Principal investigator: Wolfe, Robert R — Amino Company LLC, the
- Study coordinator: Wolfe, Robert R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.