Investigating amino acids for treating liver fat in children
Amino Acids and Pediatric Hepatic Steatosis
This study is looking at how well a special amino acid treatment called AMS2392 can help reduce liver fat in kids with non-alcoholic fatty liver disease, and it will compare the results over eight weeks to see if it really makes a difference.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Amino Company LLC, the NIH-funded |
| Lab location | 1 site (Lewes, United States) |
| Project ID | NIH-10931666 on NIH RePORTER |
What this research studies
This research focuses on non-alcoholic fatty liver disease (NAFLD), which is the most common liver disease in North America, particularly affecting children. The study aims to evaluate the effectiveness of an essential amino acid-based treatment called AMS2392 in reducing liver fat in youths diagnosed with hepatic steatosis. By conducting a randomized clinical trial, the researchers will compare the effects of this treatment over eight weeks in a controlled environment, ensuring that neither the participants nor the researchers know who receives the treatment or a placebo. This approach aims to provide robust evidence on the potential benefits of amino acids in managing liver health in children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents aged 0-17 years who have been diagnosed with hepatic steatosis.
Not a fit: Patients who do not have hepatic steatosis or those with other liver diseases unrelated to NAFLD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment option for reducing liver fat in children, potentially improving their long-term metabolic and cardiovascular health.
How similar studies have performed: Previous studies have shown success in using amino acid-based treatments for related conditions, indicating potential for this approach in pediatric hepatic steatosis.
Where this research is happening
Lewes, United States
- Amino Company LLC, the — Lewes, United States (Active)
Researchers
- Principal investigator: Wolfe, Robert R — Amino Company LLC, the
- Study coordinator: Wolfe, Robert R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.