Investigating Alpha-1 Antitrypsin Deficiency and its Impact on Lung Health
Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of Disease
This study is looking for people with Alpha-1 antitrypsin deficiency (AATD) to help us learn more about how this condition affects lung health and to find better treatments, so if you have AATD, your participation could make a difference!
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10877789 on NIH RePORTER |
What this research studies
This research focuses on Alpha-1 antitrypsin deficiency (AATD), a genetic condition that leads to low levels of a protein crucial for lung health, contributing to chronic obstructive pulmonary disease (COPD). The study aims to create a cohort of individuals with AATD to better understand the disease's natural history, treatment strategies, and clinical characteristics. By identifying biomarkers that indicate disease progression, the research seeks to enhance the understanding of how AATD affects patients and to develop more effective therapies. Participants will be involved in a collaborative effort to explore the genetic and phenotypic aspects of AATD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alpha-1 antitrypsin deficiency, particularly those experiencing symptoms related to lung health.
Not a fit: Patients without Alpha-1 antitrypsin deficiency or those with unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for patients with Alpha-1 antitrypsin deficiency.
How similar studies have performed: Previous research has shown promise in understanding AATD and its implications, but this study aims to further explore novel biomarkers and their role in disease management.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: D'armiento, Jeanine M — Columbia University Health Sciences
- Study coordinator: D'armiento, Jeanine M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.