Investigating aging and inflammation in Alzheimer's disease
Neuronal senescence and inflammation in Alzheimer's disease
['FUNDING_R37'] · SALK INSTITUTE FOR BIOLOGICAL STUDIES · NIH-11080276
This study is looking at how getting older and inflammation affect Alzheimer's disease by examining special brain cells that show signs of aging, which could help us find new ways to understand and treat the disease.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SALK INSTITUTE FOR BIOLOGICAL STUDIES (nih funded) |
| Locations | 1 site (La Jolla, UNITED STATES) |
| Trial ID | NIH-11080276 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how aging and inflammation contribute to Alzheimer's disease (AD) by studying human neurons that retain age-related characteristics. The researchers will generate induced neurons from fibroblasts, allowing them to examine the cellular processes involved in neuronal aging and AD without the rejuvenation seen in other methods. By analyzing gene expression and cellular behavior in these neurons, the study aims to uncover the interactions between cellular senescence and inflammation in the context of AD. This approach could lead to new insights into the mechanisms of the disease and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults, particularly those experiencing cognitive decline or diagnosed with Alzheimer's disease.
Not a fit: Patients with early-stage Alzheimer's or those without cognitive impairment may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease, potentially benefiting millions of patients.
How similar studies have performed: Other research has shown promise in studying aging and neurodegenerative diseases using similar cellular models, indicating a potential for success in this approach.
Where this research is happening
La Jolla, UNITED STATES
- SALK INSTITUTE FOR BIOLOGICAL STUDIES — La Jolla, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GAGE, FRED H — SALK INSTITUTE FOR BIOLOGICAL STUDIES
- Study coordinator: GAGE, FRED H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.