Investigating aging and immune function in lymphoid tissues
Core B: Tissue Specimen Core
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-10904916
This study is looking at how certain aging cells in important immune tissues, like bone marrow and thymus, affect your immune system as you get older, with the goal of finding clues that could help improve health in aging.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10904916 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the dynamics of lymphoid tissues, such as bone marrow and thymus, which play crucial roles in immune function throughout a person's life. It aims to map the presence and impact of senescent cells—cells that have stopped dividing and may contribute to age-related decline—in these tissues. By collecting and analyzing tissue specimens, the project seeks to identify biomarkers that can help characterize the spatial and phenotypic diversity of these senescent cells. This information could lead to better insights into how aging affects immune responses and overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults or individuals experiencing age-related immune dysfunction.
Not a fit: Patients who are young and do not have any age-related immune issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of immune aging and potential interventions to enhance immune function in older adults.
How similar studies have performed: Previous research has shown promising results in understanding cellular senescence and its implications for aging, indicating that this approach has potential for significant findings.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HALENE, STEPHANIE — YALE UNIVERSITY
- Study coordinator: HALENE, STEPHANIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.