Investigating aggressive lymphomas and their treatment resistance mechanisms
Project 2 Josefowicz
This study is looking into how certain aggressive lymphomas, like ABC-DLBCL and those linked to the Epstein Barr virus, grow and survive by using specific signals in our cells, with the goal of finding new ways to help patients get better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10847989 on NIH RePORTER |
What this research studies
This research focuses on understanding the aggressive nature of certain types of lymphomas, specifically activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) and Epstein Barr virus-associated lymphomas. It aims to uncover how these cancers exploit cellular signaling pathways to promote their growth and survival, making them difficult to treat. By studying the epigenetic changes and signaling mechanisms involved, the research seeks to identify potential therapeutic targets that could improve treatment outcomes for patients. The approach includes analyzing specific histone modifications that are linked to poor survival in lymphoma patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with activated B cell-like diffuse large B-cell lymphoma or Epstein Barr virus-associated lymphomas.
Not a fit: Patients with other types of lymphomas or those not affected by the specific mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve survival rates for patients with aggressive lymphomas.
How similar studies have performed: Previous research has shown promising results in targeting similar epigenetic and signaling pathways in aggressive lymphomas, indicating potential for success in this approach.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Josefowicz, Steven Zvi — Weill Medical Coll of Cornell Univ
- Study coordinator: Josefowicz, Steven Zvi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.