Investigating abnormal proteins in Alzheimer's disease
Official title: Comprehensive and Cell Type-Specific Proteogenomic Profiling of Aberrant and Mis-Processed Proteins in Alzheimer's Disease and Tauopathy Models
Funded at Northeastern University · NIH-11111911 · Data updated 2026-11-12
This study is looking at how certain proteins that don't work properly build up in the brains of people with Alzheimer's, and it hopes to find new ways to help treat the disease by analyzing samples from patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 15, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $784,596 |
| NIH project number | 1R01AG092460-01 |
| Project ID | NIH-11111911 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related tauopathies.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's or those without cognitive impairments may not benefit from this research.
What this research studies
This research focuses on understanding how abnormal and mis-processed proteins accumulate in the brains of individuals with Alzheimer's disease. By using advanced proteomic methods combined with genomic and transcriptomic data, the study aims to identify the specific proteins involved and how they differ across various brain regions and cell types. This comprehensive profiling could reveal new insights into the mechanisms of Alzheimer's and help identify potential therapeutic targets. Patients may be involved in providing biological samples to aid in this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments targeting the underlying causes of Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in using proteogenomic approaches to understand complex diseases, suggesting potential for success in this area as well.
Where this research is happening
-
Northeastern University
Boston, United States Active
Researchers
- Principal investigator: Slavov, Nikolai — Northeastern University
- Study coordinator: Slavov, Nikolai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.