Investigating a variant of RNA polymerase II involved in development and cancer
Mechanistic studies of transcription initiation and elongation functions of an RNA polymerase II variant, Pol II(G), that is implicated in development and cancer
This study is looking at a special type of RNA polymerase called Pol II(G) to see how it helps control gene activity, especially in liver and breast cancer cells, with the hope of finding new ways to treat these cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10926851 on NIH RePORTER |
What this research studies
This research focuses on understanding the functions of a specific variant of RNA polymerase II, known as Pol II(G), which plays a crucial role in the transcription process that regulates gene expression. By examining how Pol II(G) interacts with various cofactors and its impact on cell growth and differentiation, particularly in liver and breast cancer cells, the research aims to uncover mechanisms that could lead to new therapeutic strategies. Patients may benefit from insights gained about how transcriptional dysregulation contributes to cancer development and progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with breast cancer or liver-related conditions, particularly those experiencing transcriptional dysregulation.
Not a fit: Patients with conditions unrelated to transcriptional regulation or those not diagnosed with cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments targeting transcriptional dysregulation in cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of transcription factors in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Roeder, Robert G — Rockefeller University
- Study coordinator: Roeder, Robert G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.