Investigating a vaccine's ability to stop HIV replication
Immunologic and Virologic Basis of RhCMV/SIV Vaccine-Induced Replication Arrest Efficacy
['FUNDING_P01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-10895449
This study is exploring a new vaccine that uses a virus called Cytomegalovirus to help the immune system fight HIV, and it's being tested in monkeys to see how well it works and why, with hopes that it could lead to better ways to prevent and treat HIV in people.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-10895449 on ClinicalTrials.gov |
What this research studies
This research focuses on a novel vaccine approach using a virus called Cytomegalovirus (CMV) to stimulate the immune system in a way that can effectively combat HIV. By studying rhesus macaques, the researchers have shown that this vaccine can not only prevent the progression of HIV infection but also lead to the complete clearance of the virus in some cases. The study aims to understand the immune mechanisms behind this effect, particularly the role of specific immune cells and genetic factors that contribute to the vaccine's success. Patients may benefit from insights gained that could lead to new strategies for HIV prevention and treatment.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals at high risk for HIV infection or those living with HIV.
Not a fit: Patients who are not at risk for HIV or those who are already receiving effective treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a groundbreaking vaccine that effectively prevents or clears HIV infections.
How similar studies have performed: Previous research has shown promising results with similar vaccine approaches, indicating potential for significant advancements in HIV treatment.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PICKER, LOUIS J. — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: PICKER, LOUIS J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus