Investigating a unique form of the TRPV3 ion channel
Structure and Function of a Pentameric TRPV3 Channel
This study is looking at a special part of our cells called the TRPV3 ion channel, which helps with important body functions, to see how a new form of it might change how it works, especially in relation to certain diseases that could be affected by genetic changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10980650 on NIH RePORTER |
What this research studies
This research focuses on understanding the structure and function of a specific ion channel known as TRPV3, which plays a crucial role in various physiological processes. The team will explore a newly discovered pentameric form of this channel, which may be linked to changes in its activity and function. By using advanced imaging techniques, they aim to determine how this pentameric state relates to a phenomenon called pore-dilation, which affects how ions pass through the channel. The research will also investigate genetic mutations that may enhance the occurrence of this pentameric state, potentially leading to new insights into related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic mutations affecting TRPV3 or related ion channel disorders.
Not a fit: Patients without any known TRPV3-related conditions or genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for conditions related to TRPV3 channel dysfunction.
How similar studies have performed: While there has been significant research on TRP channels, the exploration of a pentameric state in TRPV3 is a novel approach that has not been extensively tested.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Scheuring, Simon — Weill Medical Coll of Cornell Univ
- Study coordinator: Scheuring, Simon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.