Investigating a unique form of the TRPV3 ion channel
Official title: Structure and Function of a Pentameric TRPV3 Channel
Funded at Weill Medical Coll of Cornell Univ · NIH-10980650 · Data updated 2026-11-12
This study is looking at a special part of our cells called the TRPV3 ion channel, which helps with important body functions, to see how a new form of it might change how it works, especially in relation to certain diseases that could be affected by genetic changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $596,111 |
| NIH project number | 1R01NS134559-01A1 |
| Project ID | NIH-10980650 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with genetic mutations affecting TRPV3 or related ion channel disorders.
✕Less likely to help
Patients without any known TRPV3-related conditions or genetic mutations may not benefit from this research.
What this research studies
This research focuses on understanding the structure and function of a specific ion channel known as TRPV3, which plays a crucial role in various physiological processes. The team will explore a newly discovered pentameric form of this channel, which may be linked to changes in its activity and function. By using advanced imaging techniques, they aim to determine how this pentameric state relates to a phenomenon called pore-dilation, which affects how ions pass through the channel. The research will also investigate genetic mutations that may enhance the occurrence of this pentameric state, potentially leading to new insights into related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for conditions related to TRPV3 channel dysfunction.
How similar studies have gone: While there has been significant research on TRP channels, the exploration of a pentameric state in TRPV3 is a novel approach that has not been extensively tested.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Scheuring, Simon — Weill Medical Coll of Cornell Univ
- Study coordinator: Scheuring, Simon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.