Investigating a unique DNA sequence that may enhance human brain development
An Ancient Neural Enhancer that has Rapidly Evolved in the Human Lineage
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11166463
This study is looking at a special piece of ancient DNA that might help us understand how our brains develop and could be linked to traits like intelligence and creativity, which could eventually help people with conditions like autism.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11166463 on ClinicalTrials.gov |
What this research studies
This research focuses on a specific ancient DNA sequence known as HAR123, which has evolved rapidly in humans and may play a crucial role in brain development. By examining how HAR123 influences the generation of neural progenitor cells, the research aims to uncover its potential impact on human-specific traits such as intelligence and creativity. The approach involves analyzing the function of HAR123 in a laboratory setting, using advanced genetic and biological techniques to understand its role in gene expression. Patients may benefit from insights gained about the genetic underpinnings of conditions like autism spectrum disorder and other cognitive traits.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with autism spectrum disorder or those interested in the genetic basis of cognitive traits.
Not a fit: Patients with conditions unrelated to cognitive development or genetic factors may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic factors influencing cognitive development and disorders, potentially informing new therapeutic strategies.
How similar studies have performed: While the specific investigation of HAR123 is novel, previous research has shown success in understanding the role of genetic enhancers in brain development.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WILKINSON, MILES FROME — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: WILKINSON, MILES FROME
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder, autism spectrum disorder, Autistic Disorder, autistic spectrum disorder