Investigating a treatment to prevent heart rhythm issues caused by pressure overload in the heart.
Therapeutic Modulation of Atrial Remodeling
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11117155
This study is looking at how a vitamin A derivative might help people with atrial fibrillation by improving heart function and reducing inflammation caused by high blood pressure in the heart.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11117155 on ClinicalTrials.gov |
What this research studies
This research focuses on atrial fibrillation (AF), a serious heart condition that can lead to strokes and other health problems. The study aims to explore how a vitamin A derivative, all-trans retinoic acid (ATRA), can prevent and reverse changes in the heart's left atrium caused by high pressure. By analyzing gene expression and using advanced sequencing techniques, the researchers hope to identify how ATRA can normalize heart function and reduce inflammation. Patients with conditions that lead to increased heart pressure may benefit from this innovative approach.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with atrial fibrillation or conditions that cause increased pressure in the heart.
Not a fit: Patients without atrial fibrillation or related heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively treat atrial fibrillation and improve heart health.
How similar studies have performed: Previous research has shown that ATRA can improve heart conduction in patients with acute promyelocytic leukemia, suggesting potential for success in treating atrial remodeling.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARK, DAVID S — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: PARK, DAVID S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.