Investigating a treatment for lymphedema using retinoic acid
Retinoic Acid Induced Lymphangiogenesis for Post-Surgical Lymphedema
This study is looking at how a substance called 9-cis retinoic acid might help grow new lymphatic vessels to improve swelling and immune issues for people with lymphedema, especially those who have had cancer surgeries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11063577 on NIH RePORTER |
What this research studies
This research focuses on lymphedema, a condition that causes swelling and immune dysfunction after lymphatic injury, often following cancer surgeries. The study aims to explore how 9-cis retinoic acid can promote the growth of lymphatic vessels, potentially restoring normal lymphatic function. By using preclinical models, researchers will investigate the mechanisms behind this process and develop a framework for future clinical applications. The ultimate goal is to provide a new therapeutic option for patients suffering from lymphedema.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have developed lymphedema following cancer treatments, particularly those who have undergone lymph node dissection.
Not a fit: Patients with lymphedema not related to surgical interventions or those with other underlying conditions affecting lymphatic function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment that alleviates the symptoms of lymphedema and improves patients' quality of life.
How similar studies have performed: Previous research has shown promising results with similar approaches in animal models, indicating potential for success in clinical applications.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Wong, Alex K. — Rutgers Biomedical and Health Sciences
- Study coordinator: Wong, Alex K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.