Investigating a toxic fragment of amyloid beta linked to Alzheimer's disease
Purification and Characterization of a toxic AD associated intracellularly generated amyloid beta fragment
This study is looking at a harmful form of a protein linked to Alzheimer's disease to better understand how it affects the brain, with the hope of finding new ways to treat the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10511148 on NIH RePORTER |
What this research studies
This research focuses on understanding a specific toxic form of amyloid beta, a protein associated with Alzheimer's disease (AD). Researchers will generate and analyze these amyloid beta aggregates found in the brains of individuals with AD, which are not present in cognitively normal brains. By characterizing these aggregates, the study aims to clarify their role in the progression of Alzheimer's disease and potentially identify new therapeutic targets. The approach involves advanced techniques to isolate and study these proteins at a molecular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those exhibiting symptoms of cognitive decline.
Not a fit: Patients with other forms of dementia that are not related to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into Alzheimer's disease mechanisms and pave the way for more effective treatments.
How similar studies have performed: While research on amyloid beta has been extensive, this specific focus on toxic oligomeric forms is relatively novel and has not been extensively tested.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Sierks, Michael R — Arizona State University-Tempe Campus
- Study coordinator: Sierks, Michael R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.