Investigating a therapy to repair myelin in nerve disorders
Myelin Junction Therapy in Peripheral Neuropathies
This study is looking at ways to fix the protective covering around nerve fibers that gets damaged in conditions like multiple sclerosis, using mice to find new treatment options that could help people with these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10792961 on NIH RePORTER |
What this research studies
This research focuses on understanding how to repair myelin, the protective sheath around nerve fibers, which is damaged in various neurological disorders. By studying specific proteins and pathways involved in myelin junctions, the researchers aim to identify molecular targets that can be manipulated to restore myelin integrity. The approach involves using a mouse model that mimics human conditions like hereditary neuropathy and multiple sclerosis, allowing for insights into potential therapeutic strategies. Patients may benefit from advancements in treatment options for demyelinating diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with demyelinating conditions such as Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy, or multiple sclerosis.
Not a fit: Patients with non-demyelinating neurological disorders or those without significant myelin damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that restore myelin and improve nerve function in patients with demyelinating disorders.
How similar studies have performed: Previous research has shown promise in targeting myelin repair mechanisms, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Houston, United States
- Methodist Hospital Research Institute — Houston, United States (Active)
Researchers
- Principal investigator: Li, Jun — Methodist Hospital Research Institute
- Study coordinator: Li, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.