Investigating a target for treating age-related blood diseases
Targeting 15-PGDH in Age-Related Hematologic Disease
['FUNDING_R21'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10734073
This study is looking at how getting older affects the way our bodies make blood cells and how this might lead to blood cancers, especially in older adults, by focusing on a specific enzyme that could help find better treatments for these conditions.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10734073 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how aging affects blood cell production and the development of blood cancers, particularly in older adults. It examines the role of a specific enzyme, 15-PGDH, and its impact on hematopoietic stem cells, which are crucial for generating blood cells. By studying the changes in these stem cells as people age, the research aims to identify potential therapeutic targets that could improve treatment outcomes for age-related hematologic diseases. Patients may be involved in trials that explore new treatment options based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those diagnosed with hematologic malignancies such as leukemia or lymphoma.
Not a fit: Patients who are younger or do not have age-related blood diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve the management and outcomes of blood cancers in older patients.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in hematologic diseases, indicating potential for success in this approach.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DESAI, AMAR — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: DESAI, AMAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.