Investigating a subtype of Meniere's disease linked to a genetic disorder
Official title: The Phex Pathway: Mechanisms Underlying a Meniere's Disease Subtype
Funded at Massachusetts Eye and Ear Infirmary · NIH-11113588 · Data updated 2026-11-12
This study is looking at a specific type of Meniere's disease linked to a genetic condition called X-linked hypophosphatemia, using mice to better understand how problems in the inner ear develop, which could help find new ways to treat this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Eye and Ear Infirmary NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $194,400 |
| NIH project number | 1K08DC022696-01 |
| Project ID | NIH-11113588 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Meniere's disease, especially those exhibiting symptoms consistent with the MDhp subtype or those with a history of X-linked hypophosphatemia.
✕Less likely to help
Patients with other forms of Meniere's disease or those without any auditory or vestibular symptoms may not benefit from this research.
What this research studies
This research focuses on understanding a specific subtype of Meniere's disease (MDhp) that is associated with a genetic condition known as X-linked hypophosphatemia (XLH). The study utilizes a mouse model that mimics the auditory and vestibular symptoms seen in humans with this subtype. By examining the PHEX signaling pathway, the researchers aim to uncover the mechanisms that lead to the maldevelopment of the endolymphatic sac, which is crucial for inner ear function. This work could provide insights into the underlying causes of MDhp and potentially lead to new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of Meniere's disease, particularly for patients with the MDhp subtype.
How similar studies have gone: Previous research has shown success in using animal models to study auditory disorders, suggesting that this approach could yield valuable insights into Meniere's disease.
Where this research is happening
-
Massachusetts Eye and Ear Infirmary
Boston, United States Active
Researchers
- Principal investigator: Chari, Divya a. — Massachusetts Eye and Ear Infirmary
- Study coordinator: Chari, Divya a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.