Investigating a specific type of brain cell related to Alzheimer's disease
Interrogation of a human microglia phenotype associated with Alzheimer's disease
This study is looking at special brain cells called microglia to see how they act in Alzheimer's disease, with the goal of finding new ways to help treat or prevent the condition, and patients may be asked to help by sharing samples or information.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10884107 on NIH RePORTER |
What this research studies
This research focuses on microglia, the immune cells in the brain, which play a crucial role in maintaining brain health. The study aims to understand how these cells behave in Alzheimer's disease, particularly how different subtypes of microglia may contribute to the disease's progression or protection. By analyzing these cells through advanced techniques like single-cell RNA sequencing, researchers hope to identify potential targets for new therapies that could modify or prevent Alzheimer's disease. Patients may be involved in providing samples or data to help elucidate these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those at risk due to genetic factors.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that modify the course of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding microglial roles in neurodegenerative diseases, suggesting this approach has potential for success.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Olah, Marta — Columbia University Health Sciences
- Study coordinator: Olah, Marta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.