Investigating a specific RNA marker for diabetic retinopathy
miR-92a as a biomarker of diabetic retinopathy
This study is looking at a special marker in the blood that could help doctors spot early signs of diabetic retinopathy, a serious eye condition for people with diabetes, so they can take action before it leads to vision loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10909122 on NIH RePORTER |
What this research studies
This research focuses on diabetic retinopathy (DR), a common complication of diabetes that can lead to blindness. The study aims to identify a specific RNA marker, miR-92a, found in circulating angiogenic cells (CACs) that may indicate retinal vascular health. By analyzing the RNA signatures in these cells, researchers hope to develop a reliable early diagnostic tool for DR. The approach includes using machine learning models and animal models to understand the relationship between miR-92a levels and inflammation in the retina.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who are at risk of developing diabetic retinopathy.
Not a fit: Patients without diabetes or those who do not have any signs of diabetic retinopathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to an early diagnostic tool for diabetic retinopathy, potentially preventing vision loss in patients.
How similar studies have performed: Other research has shown promise in using RNA markers for diagnosing various conditions, suggesting that this approach may yield successful results.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Bhatwadekar, Ashay D — Indiana University Indianapolis
- Study coordinator: Bhatwadekar, Ashay D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.