Investigating a specific receptor's role in chronic orofacial pain
Official title: Role of Understudied aGPCRs in Orofacial Neuropathic Pain
Funded at University of Florida · NIH-10844733 · Data updated 2026-11-12
This study is looking at a specific receptor in the body that might help us understand and manage chronic pain in the face and mouth, especially after nerve injuries, so that we can find better ways to relieve pain for patients like you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $419,375 |
| NIH project number | 1R21DE033639-01 |
| Project ID | NIH-10844733 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic orofacial pain, particularly those with a history of nerve injury.
✕Less likely to help
Patients with acute pain conditions or those not experiencing orofacial pain may not benefit from this research.
What this research studies
This research focuses on a type of receptor known as Adhesion G-Protein Coupled Receptors (aGPCRs) that may play a significant role in chronic orofacial pain. The study aims to understand how these receptors, particularly ADGRD1, are involved in pain signaling after nerve injury. By examining the expression of ADGRD1 in sensory neurons and its activation mechanisms, the research seeks to identify potential therapeutic targets for pain management. Patients may benefit from new pain relief strategies developed from this understanding.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic orofacial pain, improving quality of life for affected patients.
How similar studies have gone: While the specific receptor ADGRD1 has not been extensively studied in pain contexts, similar approaches targeting G-Protein Coupled Receptors have shown promise in pain management.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Caudle, Robert M — University of Florida
- Study coordinator: Caudle, Robert M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.