Investigating a specific receptor's role in chronic orofacial pain
Role of Understudied aGPCRs in Orofacial Neuropathic Pain
['FUNDING_R21'] · UNIVERSITY OF FLORIDA · NIH-10844733
This study is looking at a specific receptor in the body that might help us understand and manage chronic pain in the face and mouth, especially after nerve injuries, so that we can find better ways to relieve pain for patients like you.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10844733 on ClinicalTrials.gov |
What this research studies
This research focuses on a type of receptor known as Adhesion G-Protein Coupled Receptors (aGPCRs) that may play a significant role in chronic orofacial pain. The study aims to understand how these receptors, particularly ADGRD1, are involved in pain signaling after nerve injury. By examining the expression of ADGRD1 in sensory neurons and its activation mechanisms, the research seeks to identify potential therapeutic targets for pain management. Patients may benefit from new pain relief strategies developed from this understanding.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic orofacial pain, particularly those with a history of nerve injury.
Not a fit: Patients with acute pain conditions or those not experiencing orofacial pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic orofacial pain, improving quality of life for affected patients.
How similar studies have performed: While the specific receptor ADGRD1 has not been extensively studied in pain contexts, similar approaches targeting G-Protein Coupled Receptors have shown promise in pain management.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAUDLE, ROBERT M — UNIVERSITY OF FLORIDA
- Study coordinator: CAUDLE, ROBERT M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.